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Venomous animals have specialized venom delivery apparatus such as nematocysts, stings, and fangs in addition to the poisonous organs consisting venom gland or sac, which produce and stock the venom. ...Snake is one of the major venomous animals, of which fangs are connected to the venom gland to inject the venom into prey. Snake’s venomous fangs showed the unique characteristics including mechanical strength and chemical stability. Especially, Protobothrops flavoviridis (habu) snake fangs showed the resistance against its venom digestive proteases, whereas the bones and teeth of mouse were completely digested in the gastrointestinal tract, although habu fangs were also drawn into the body with the prey. These observations suggest that structural differences exist between venomous fangs and mammalian bones and teeth.
In this study, to reveal the molecular properties of venomous snake fangs, the matrix proteins of P. flavoviridis (habu) snake venom fang were analyzed by using proteomics experiments using 2D-PAGE and TOF MS/MS analyses. As a result, several biomineralization-related proteins such as vimentin, tectorin, adaptin, and collagen were identified in the venomous fang matrix proteins. Interestingly, the inhibitory proteins against venomous proteins such as metalloproteinase and PLA2 were also identified in fang’s matrix proteins.続きを見る
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