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Half-Lives of Dioxin-Like-Compounds in Blood are Prolonged in Yusho Patients
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| Abstract | Yusho, the mass food poisoning, occurred in western Japan in 1968. PCBs and dioxin like compounds such as 2,3,4,7,8-PeCDF were detected as causal chemicals for Yusho. Our group have measured blood con...centrations of dioxin-like compounds and analyzed their half-lives. In our previous studies, we have found two groups ; one group has 7-10 years of half-lives as reported by other researchers, and the other group has near infinite half-lives. In addition, the number of patients in group showing 7-10 years of half-lives decreased and the number in group with near infinite half-lives increased. However, those changes were not evaluated in individual patient since follow-up period was relatively short to analyze the individual half-live. Therefore, we now intend to evaluate the long-term change of half-life in individual patient. Our preliminary analysis indicates that the half-life of 2,3,4,7,8-PeCDF appears to be prolonged in each patient. Considering the recent low levels of environmental contamination of dioxins and their related compounds, the prolonged half-life of blood concentration of 2,3,4,7,8-PeCDF points its deteriorated excretion.show more |
| Table of Contents | はじめに 半減期の計算法 半減期が10年程度とほとんど排出しない二つのグループが存在 半減期が10 年程度のグループが減少し，ほとんど排出しないグループが増加 測定時期による患者個人の半減期の影響 ［最新の研究成果］ まとめ |
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| Created Date | 2019.07.22 |
| Modified Date | 2021.03.03 |