Glycopolymers Mimicking GM1 Gangliosides: Cooperativity of Galactose and Neuraminic Acid for Cholera Toxin Recognition - Collections | Kyushu University Library

＜journal article＞
Glycopolymers Mimicking GM1 Gangliosides: Cooperativity of Galactose and Neuraminic Acid for Cholera Toxin Recognition

Creator	Creator Name Terada, Yuhei 寺田, 侑平テラダ, ユウヘイ Affiliation Affiliation Name Department of Chemical Systems and Engineering, Kyushu University 九州大学大学院工学府化学システム工学専攻
	Author PID K003810 Creator Name Hoshino, Yu 星野, 友ホシノ, ユウ Affiliation Affiliation Name Department of Chemical Systems and Engineering, Kyushu University 九州大学大学院工学研究院化学工学部門
	Author PID K003608 0000-0001-8590-6079 Creator Name Miura, Yoshiko 三浦, 佳子ミウラ, ヨシコ Affiliation Affiliation Name Department of Chemical Systems and Engineering, Kyushu University 九州大学大学院工学研究院化学工学部門
Language	English
Publisher	Wiley
Date	2019-04-01
Source Title	Chemistry : an Asian journal
Vol	14
Issue	7
First Page	1021
Last Page	1027
Publication Type	Accepted Manuscript
Access Rights	restricted access
Rights	著作権処理未完了のため本文ファイル非公開
Rights	Public access to the fulltext file is restricted by copyright reason
Related DOI	isIdenticalTo https://doi.org/10.1002/asia.201900053
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Abstract	Glycopolymers mimicking GM1 gangliosides were synthesized by incorporating multiple types of carbohydrates into the polymer backbone. The glycopolymers were immobilized onto gold surfaces, and the int...eractions with the cholera toxin B subunit (CTB) were analyzed using surface plasmon resonance imaging. The glycopolymer containing both galactose and neuraminic acid showed enhanced recognition of CTB. The interaction was enhanced mainly because of an improvement in the dissociation process by the binding of the neuraminic acid group in the GM1 binding pocket. This cooperativity of galactose and neuraminic acid was achieved by incorporation into the same flexible polymer backbone, and the importance of the close placement of galactose and neuraminic acid groups was revealed. These results will be valuable in medical fields and also for the development of biofunctional materials.show more

Details

PISSN	1861-4728
EISSN	1861-471X
NCID	AA12151701
Record ID	2320131
Subject Terms	cluster glycoside effect
	glycomimetics
	glycopolymers
	molecular recognition
	surface plasmon resonance imaging
Funding Information	Funder Name 日本医療研究開発機構 (AMED) Japan Agency for Medical Research and Development Award Number 18fk0108054h0002 Award Title プラスチック抗体技術を用いた腸管出血性大腸菌感染症の新規治療法の開発
	Funder Name 日本学術振興会 Japan Society for the Promotion of Science (JSPS) Award Number 15H03818 Award Title 精密重合を基盤にした糖鎖高分子ナノメディシンの開発 Glycopolymer nanomedicine based on the controlled polymerization
	Funder Name 日本学術振興会 Japan Society for the Promotion of Science (JSPS) Award Number https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04420/ Award Title 糖モジュール法を活用した生理活性糖ミミックの合成 Synthesis of oligosaccharide mimics with glycol-module method
	Funder Name 日本学術振興会 Japan Society for the Promotion of Science (JSPS) Award Number 17J03810 Award Title 糖鎖高分子を用いたマルチ光学バイオセンシング Multi-optical biosensing using glycopolymers
Created Date	2019.06.25
Modified Date	2019.07.02