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| Abstract |
The immunohistological localization of peroxisome proliferator-activated receptorα(PPARα) and PPARγ was examined in 28 pilosebaceous units in 10 paraffin-embedded normal human skin specimens. Rabbit p...olyclonal antibody against human PPARαand monoclonal antibody against human PPARγwere used as specific primary antibodies. The nuclear and cytoplasmic expression of PPARαwas detected in basal to differentiated sebocytes. In contrast, the expression of PPARγwas confined to nuclei of suprabasal to early-differentiated sebocytes. The nuclear PPARγexpression was present only occasionally in the basal sebocytes. These results suggest that PPARαand PPARγare integral parts of sebocyte differentiation in human sebaceous glands.
ヒト脂腺におけるperoxisome proliferator-activated receptor a (PPARα) とPPARγの免疫組織学的発現を，パラフィン包埋した正常皮膚（N=10）中の28 個の毛囊脂腺系で検討した．ウサギポリクロナル抗ヒトPPARα抗体とマウスモノクロナル抗ヒトPPARγ抗体を一次抗体として用いた．PPARαは基底層および分化した脂腺細胞の核内および細胞質に一様に染色された．PPARγは，基底層上層から分化初期の脂腺細胞の核内に染色された．またPPARγは基底層のごく一部の脂腺細胞の核内にも認められた．これらの結果は，PPARαとPPARγが脂腺分化に関与していることを示唆していると考えたshow more
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