<博士論文>
アルツハイマー病患者とマウスモデルの大脳皮質における遺伝子発現の比較プロファイリングから明らかになったアミロイドーシスと神経炎症の関係

作成者
本文言語
学位授与年度
学位授与大学
学位
学位種別
出版タイプ
アクセス権
関連DOI
概要 Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an i...mportant role in the development and progression of AD. However, the extent to which these events contribute to the Aβ pathologies remains unclear. We performed inter-species comparative gene expression profiling between AD patient brains and the App^<NL-G-F/NL-G-F> and 3xTg-AD-H mouse models. Genes commonly altered in App^<NL-G-F/NL-G-F> and human AD cortices correlated with the inflammatory response or immunological disease. Among them, expression of AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increased in the App^<NL-G-F/NL-G-F> cortex as Aβ amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the 3xTg-AD-H and human AD cortices correlated with neurological disease. The App^<NL-G-F/NL-G-F> cortex also had altered expression of genes (Abi3, Apoe, Bin2, Cd33, Ctsc, Dock2, Fcer1g, Frmd6, Hck, Inpp5D, Ly86, Plcg2, Trem2, Tyrobp) defined as risk factors for AD by genome-wide association study or identified as genetic nodes in late-onset AD. These results suggest a strong correlation between cortical Aβ amyloidosis and the neuroinflammatory response and provide a better understanding of the involvement of gender effects in the development of AD.続きを見る

本文ファイル

med3153 pdf 5.17 MB 287 本文
med3153_abstract pdf 114 KB 81 要旨
med3153_review pdf 176 KB 81 審査結果要旨

詳細

レコードID
査読有無
権利関係
関連PubMed ID
報告番号
学位記番号
授与日(学位/助成/特許)
受理日
部局
登録日 2018.08.07
更新日 2018.10.11

この資料を見た人はこんな資料も見ています