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＜博士論文＞
施設入所高齢者における舌苔マイクロバイオームと肺炎死亡の関連
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| 論文調査委員 | |
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| 概要 | Background:Aspiration of oral debris, containing dense oral bacteria, is a major cause of pneumonia in elderly adults. This study investigated the relationship between tongue microbiota composition an...d incidence of pneumonia-related deaths, in nursing home residents. Methods:The subjects were assessed for health conditions, including their tongue microbiota, at baseline. We determined tongue microbiota profiles by 16S ribosomal RNA gene sequencing and clustering approach. All subjects (n = 173) were followed prospectively for a median of 19 months to assess the incidence of all-cause death, including pneumonia-related death. We evaluated risk estimates of microbiota effects on death using multivariate Cox proportional hazards regression analysis. Results:Tongue microbiota were classified into two community types: type I was dominated by Prevotella and Veillonella species, while type II was dominated by Neisseria and Fusobacterium species. The subjects with type I microbiota exhibited a significantly greater risk of all-cause death (adjusted hazard ratio [aHR] = 3.79, 95% confidence interval [CI] = 1.38-10.39) and pneumonia-related death (aHR = 13.88, 95% CI = 1.64-117.21), than those with type II microbiota. There was no significant association between microbiota type and other-cause death. Conclusions:The tongue microbiota type was significantly associated with an increased mortality risk from pneumonia in nursing home residents.続きを見る |
本文ファイル
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dent0761_abstract
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257 KB | 219 | 要旨 | |
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dent0761_review
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251 KB | 116 | 審査結果要旨 |
詳細
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| 登録日 | 2018.05.30 |
| 更新日 | 2022.02.22 |