|
|
| 作成者 |
|
| 論文調査委員 |
|
|
|
|
|
| 本文言語 |
|
| 学位授与年度 |
|
| 学位授与大学 |
|
|
|
| 学位 |
|
| 学位種別 |
|
| アクセス権 |
|
| 関連DOI |
|
| 概要 |
AIMS:The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS).
METHODS AND RESULTS:We reviewed 60 cases of surgically resected ULMSs and investigated conventional c...linicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study.
CONCLUSIONS:IMP3 expression in ULMS could be a marker of a poor prognosis.続きを見る
|
Mendeley出力
med3098_abstract