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＜博士論文＞
悪性リンパ腫の骨髄浸潤の診断に有用な検査項目の検討
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| 概要 | INTRODUCTION:This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. METH...ODS:We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. RESULTS:In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P < .0001; MgK, P = .0384). The rate of peripheral blood involvement by malignant lymphoma (PBI), red blood cell distribution width (RDW), D-dimer (DD), soluble interleukin-2 receptor (sIL2R), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) was significantly higher in the BMI group than in the non-BMI group (PBI, P < .0001; RDW, P = .0190; DD, P = .0006; sIL2R, P < .0001; AST, P = .0256; LDH, P = .0002). In multivariate analysis, PBI, PLT, sIL2R, and MgK levels were independent predictors of BMI. CONCLUSION:PBI, PLT, sIL2R, and MgK may be the useful laboratory markers for BMI diagnosis.続きを見る |
本文ファイル
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med3082
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med3082_abstract
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58.6 KB | 1,313 | 要旨 | |
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med3082_review
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80.0 KB | 764 | 審査結果要旨 |
詳細
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| 登録日 | 2018.05.30 |
| 更新日 | 2020.01.31 |