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A study was conducted to clarify the effect of the menstrual cycle on metabolic response to prolonged aerobic exercise in regularly menstruating healthy young women aged 22 to 24 years. There was si...gnificant variability in the basal body temperature between the follicular phase and the luteal phase. Determination of the luteal phase was based on blood progesterone levels (mean±SD; follicular phase 0.66±0.23 ng/ml; luteal phase 10.2±5.5 ng/ml). In the follicular phase and luteal phase, six of the women (mean±SD; body fat 23.7±4.6%; Vo2max 37.1±4.8 ml/kg/min) were subjected to 40 min of bicycle ergometer exercise at an intensity representing 55% of their measured Vo2max. Venous blood samples obtained before and during exercise (10, 20, 30 and 40 min) were analyzed for levels of substrates (glucose, FFA, acetoacetic acid) and hormones (LH, FSH, E2, progesterone, insulin, adrenaline, noradrenaline, leptin). Exercise-induced changes in substrate and hormone patterns were compared in the follicular phase and luteal phase of the menstrual cycle. The relative intensities of exercise were similar in both phases (means±SD, Vo2max values corresponding to 54.6±4.2% in follicular phase and 55.3±2.9% in luteal phase: p>0.05). The 40-min respiratory exchange ratio (R) was significantly lower in the follicular phase than in the luteal phase (p<0.05). For both cycle phases, blood glucose and insulin levels remained relatively constant throughout the exercise period. The lower basal FFA concentrations observed in the follicular phase did not reach statistical significance. When compared with resting values and, contrary to observations in the luteal phase, FFA concentrations in the follicular phase were higher at the end of exercise. In both phases, increases in blood noradrenaline and adrenaline concentrations were observed during the exercise period. There were no observable changes in leptin levels during exercise in either the follicular or the luteal phase. The present results demonstrate that most of the substrates and endocrine responses to prolonged aerobic exercise are similar in the follicular and luteal phases of the menstrual cycle. Therefore it may be concluded that the phase of t.he menstrual cycle has little or no effect on exercise-induced metabolic responses. However, in the follicular phase, several unexpected responses occurred: 1) the respiratory exchange ratio was significantly lower, 2) no exercise-induced glucose or insulin increment was observed, 3) there was a greater FFA response.
本研究は，性周期phaseの異なる低体温期と高体温 期における有酸素性運動中の代謝・ホルモン系の動態を比較検討したものである。被験者は22歳から24歳ま での正常な性周期を有する健康な6人の女性である。低体温期と高体温期では基礎体温に統計的な有意差が みられたが，最終的なphaseの確定は血中プロゲステロン・レベルによって行った。 被験者は，低体温期と高体温期にあらかじめ測定した最大酸素摂取量の55%強度で40分間の自転車エルゴ メータ運動を実施した。安静時から運動開始後10,20,30,40分に採血し，糖・脂質およびホルモン・レベル を分析した。検査項目は，グルコース，TG，FFA，アセト酢酸，E2，プロゲステロン，インスリン，ア ドレナリン，ノルアドレナリン，レプチンである。両phaseにおける運動中のHRやVo2には有意な差は みられなかったが，運動開始40分後の呼吸交換比(R)は低体温期の方が有意に低かった(p<0.05)。運動 中のグルコースとインスリンのレベルには，両Phase間に有意な差はみられなかった。FFAは，安静時で 低体温期の方が低い値を示したが，運動中のFFAレベルは高体温期より活発な上昇傾向を示した。また， 両phaseともカテコラミンは運動時間の経過とともに上昇傾向を示した。 これらの結果より，運動による両Phaseへの影響にはほとんど差がないと考えられるが，結果をまとめる と，低体温期では以下の3点が顕著であった:1)呼吸交換比は低体温期の方が低かった，2)インスリン とグルコースのレベルは運動によってほとんど影響を受けなかった，3)FFAの代謝は活発であった。続きを見る
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