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Insulin resistance is a recognized characteristics of several disease states including obesity, non-insulin dependent diabetes mellitus (NIDDM), essential hypertension and atheroscelerotic cardiovasc...ular disease. Women in their childbering years have a 2-3 times lower incidence of coronary heart disease than in men. Similar observation has also been documented in incidence of NIDDM. This difference has been attributed to factors such as favorable sex hormones, lipids, and coagulation profiles. Especially, sex steroid hormones were also important regulators of lipid and gulcose metabolism in men and women. Significant sex difference of insulin sonsitivity evaluated by hyperinsulinemic euglycemic clamp method was demonstrated in several studies. Insulin sensitivity evaluated as glucose infusion rate (GIR; mg/kg/min) per whole body and lean body mass, and GIR in skeletal muscle using [18F]fluorp-2-deoxy- D-glucose (18FDG) and positron emission tomography (PET) under calmp in women was significantly higher than that in men. It is reported that this phenomenon is an independent of age, physical fitness and body mass index in both sexes. In this review, we would like to mainly discussed the effects of and role of sex hormones concerning the sex difference of insulin sensitivity.続きを見る
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