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We investigated 408 subjects (145 males and 263 females), age 23 to 82 years old with an average of about 59, living in Takashima island, and discussed in terms of blood pressure and its related varia...bles. Of these, 220 subjects (53.9%) were normotensives (NT), 92(22.5%) borderline hypertensives (BHT) and the remainders (23.6%) hypertensives (HT), that included the subjects receiving antihypertensive drugs. In order to avoid the influence of these drugs on blood chemistries, the analyses were carried out on NT, BHT and HT without antihypertensive drugs. Systolic (SBP) and/or diastolic blood pressures (DBP) significantly positively correlated with body weight, serum Na, Ca, creatinine, uric acid, total cholesterol, triglyceride and total protein in males and with age, pulse rate, serum Ca, uric acid, GOT, total protein and serum Ca/Mg ratio in females. Correlation coefficients adjusted for age were calculated between SBP or DBP and other variables as the age itself affected many variables. SBP and/or DBP significantly positively correlated with pulse rate, total protein, uric acid, cholesterol, triglyceride, serum Ca, Cl and serum Ca/Mg ratio in males, and with pulse rate, total protein, serum Ca, Cl, serum Ca/Mg ratio, 24-h urinary Na excretion and 24-h urine Na/K ratio in females. These results suggest that Ca and Mg as well as Na and K may be factors partly influencing the pathogenesis of hypertension, and extensive clinical researches concerning Ca and Mg metabolism are necessary to clarify the mechanism of hypertension.続きを見る
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