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We studied the usefulness and the limitation of nuclepore membrane in the estimation of red cell deformability, and applied the method to exercise physiology. The following observations were made in a... young male athlete during exercise, which was done by bicycle for 30 minutes at the lactate threshold level. Red cell filterability (RCF): RCF was measured by Negative Pressure Red Cell Filtration System (Isogai's system. NPRCFS). Whole blood viscosity (WBV): The cone-plate viscometer was used to study blood viscosity at various shear rate. (shear rate: :23 sec-1〜230 sec-1). Plasma viscosity (PV): The microcapillary viscometer was used, denoting plasma viscosity as relative viscosity with water. Blood chemical data including catecholamine were also detected. 1) Air flow rate in each 10 membranes, which were selected from the two different Lot No., (54 N 4 A 6, 54 G 6 E 8) were 60.9±3.2(l/min/cm2) and 84.6±4.41(l/min/cm2), respectively. 2) RCF markedly decreased during exercise and the decrease of RCF strongly correlated with the increase of catecholamine, heart rate and potassium. These results suggest that the nuclepore membrane is useful for the measurement of RCF, and that exercise induce the increase of catecholamine and its β-stimulation for red cell membrane, resulting in the decrease of RCF. Hereafter, RCF will become to play an important role in the exercise physiology. (Journal of Health Science Kyushu University, 10: 103-108, 1988)続きを見る
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