Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure - 九大コレクション

＜紀要論文＞
Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure

作成者	作成者名 LI, Lixia 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
	作成者名 DONG, Kejun 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
	作成者名 CHEN, Chen 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
	作成者名 CHEN, Kun 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
	作成者名 SHI, Yanhong 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University
	作成者名 QIU, Xuchun 所属機関所属機関名 Institute of Environmental Health and Ecological Security, School of the Environment and Safety Engineering, Jiangsu University 所属機関所属機関名 Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology
	著者識別子 K001666 40363329 作成者名 SHIMASAKI, Yohei 島崎, 洋平シマサキ, ヨウヘイ所属機関所属機関名 Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University 九州大学大学院農学研究院
	著者識別子 K001575 70176874 作成者名 OSHIMA, Yuji 大嶋, 雄治オオシマ, ユウジ所属機関所属機関名 Laboratory of Marine Environmental Science, Faculty of Agriculture, Kyushu University 九州大学大学院農学研究院
本文言語	英語
出版者	Faculty of Agriculture, Kyushu University
出版者	九州大学大学院農学研究院
発行日	2022-09
収録物名	九州大学大学院農学研究院紀要
巻	67
号	2
開始ページ	181
終了ページ	187
出版タイプ	Version of Record
アクセス権	open access
Crossref DOI	https://doi.org/10.5109/4797825

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PISSN	0023-6152
NCID	AA00697606
レコードID	4797825
主題	Amitriptyline
	Zebrafish
	Neurotransmitter levels
	Behavior
	Recovery
注記	Amitriptyline (AMI) is a tricyclic antidepressant (TCA) that has been widely used to treat depression. The widespread use has caused AMI to enter the environmental waters with a maximum concentration of μg/L. However, knowledge of its persistent toxic effects on fish is still limited. Therefore, this study exposed female zebrafish to 10 μg/L of AMI for seven days, followed by a 21–day recovery in AMI–free water. The results showed that AMI could induce persistent or delayed hypoactivity and abnormal social behavior in zebrafish. AMI exposure also significantly altered the brain levels of 5–HT, 5–HIAA, and ACH. Correlation analysis revealed that 5–HT and ACH were negatively correlated with locomotor activity, and 5–HT was also positively correlated with social interaction. Our finding demonstrated that AMI could cause persistent abnormal behavior in zebrafish and alter the brain neurotransmitter levels in zebrafish, suggesting that those long–term impact should not be ignored.
助成情報	助成機関名 Natural Science Foundation of Jiangsu Province of China 研究課題番号 BK20191433
登録日	2022.09.05
更新日	2023.03.07

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＜紀要論文＞ Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure

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＜紀要論文＞
Recovery Pattern of Behavioral Responses in Female Zebrafish to Short–term Amitriptyline Hydrochloride Exposure