| 概要 |
To investigate chronic immune effects of polychlorinated biphenyl (PCB) and 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), CD4 positive T helper 0 (Th0), Th1 and Th2 cells in peripheral blood were studied... in 186 patients with Yusho and 31 control subjects in 2019. Significant relationships between the concentrations of PCB in blood and the percentages of Th0 and Th2 cell subpopulation were observed. However, there was no correlation between the blood 2,3,4,7,8-PeCDF levels and the percentages of Th0, Th1 or Th2 cell subpopulation. The percentages of Th0 and Th2 cell subpopulation were significantly increased in the Yusho patients with high PCB levels compared with those in the subjects with low PCB levels. The percentages of Th2 cell subpopulation were significantly increased in the Yusho patients with high 2,3,4,7,8-PeCDF levels compared with those in the subjects with low 2,3,4,7,8-PeCDF levels. We conclude that the percentages of Th0 and Th2 cell subpopulation increase in the Yusho patients with high PCB levels, and it may be associated with PCB levels in blood.続きを見る
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Mendeley出力
112_2_p164