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Our previous studies have revealed that maternal exposure to2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) attenuates the hypothalamic biosynthesis of gonadotropin-releasing hormone (GnRH) in male offspri...ng, thereby imprinting sexual immaturity. To clarify the mechanisms underlying such reductions in GnRH, we examined the effects of TCDD on the number and/or form of GnRH neurons. Maternal exposure to TCDD was found to have little effect on the number or location of GnRH neurons in male offspring at gestational day 20 (GD20), postnatal day 4 (PND4), PND7, PND14, or PND28. However, maternal exposure to TCDD was observed to attenuate the number of bipolar GnRH neurons in the male offspring at PND14 and PND28, although no similar effect was observed for unipolar neurons. Furthermore, we detected no obvious effect of TCDD on the axonal length of GnRH neurons. These findings indicate that TCDD reduces the number of bipolar GnRH neurons beginning at PND14 when it causes GnRH attenuation. TCDD may thus elicit the attenuation of GnRH neurons in a bipolar neuron-selective manner.続きを見る
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Mendeley出力
112_2_p148