<紀要論文>
Effects of Isoproterenol, a Non-Selective β-Agonist, on Lipid Metabolism of Rats : In Vitro and In Vivo Study

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概要 It is believed that β-adrenergic receptors are involved in fat metabolism through the induction of lipolysis. On the other hand, different dietary fats show different pattern of fat accumulation in an...imal body. In this study, first, in vitro lipolytic effect of isoproterenol in rat adipocyte has been studied, then its interaction with different dietary fats on fat accumulation in animal body (in vitro) has been studied. For in vitro study, adipocytes isolated from epidydimal fat were incubated with 10^<-5> to 10^<-9>M isoproterenol and freed glycerol content was measured as an index of lipolysis. For animal study, forty-eight male SD rats were divided into agonist-intaked and control groups and both of them were fed diets containing 12% of either beef tallow (BT), canola oil (CO), olive oil (OO) or safflower oil (SO) as fat source. After 4 weeks, the rats were killed and their abdominal fat mass and liver were dissected and weighed. The results of in vitro studies showed a potent lipolytic effect of isoproterenol on rat adipocytes. The pD2 values for isoproterenol was 7.345±0.018. Amount of accumulated abdominal fat was not different between agoinst-intaked and control. It was concluded that, although isoproterenol had a potent lipolytic effect on rat adipocytes in vitro, its in vivo effect was not obvious, possibly due to less bioavailability of the agonist at adipocytes level in situ.続きを見る

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登録日 2012.08.02
更新日 2021.02.05

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