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The two types of purine auxotrophs of Streptomyces azureus required adenine and other purines at less than 50 fig/ml for their growth, but their spore formation was inhibited by excess adenine and hyp...oxanthine. An excess of these purines stimulated a remarkable accumulation of intermediates (especially AICAR, 5’mphosphoribosyl-5-amino-4-imidazole carboxamide) of purine biosynthesis in the mutants. The inhibitory effect of excess purines on spore formation was proportional to the amount of intermediates accumulated. No such inhibition and intermediate accumulation occurred with guanine and xanthine and with the wild-type strain. An adenine related compound AICA (5-amino-4-imidazole carboxamide) suppressed the inhibitory effect of the purines and bypassed the accumulation of the intermediates. The mutants produced very low levels of the antibiotic thiostrepton. AICA also stimulated the thiostrepton production of mutants as well as their growth. AICA enhances the mycelial metabolism, and thus the accumulation of intermediates, which suppresses spore formation and thiostrepton production, may be prevented in the mutants.続きを見る
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