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Clostocin 0 is a phage tail-like bacteriocin produced by Closlridium saccharoperbutylacetonicum (ATCC 13564). One particle of clostocin 0 had an activity to kill one ensitive organism. The biosynthesi...s of macromolecules (protein, RNA and DNA) in sensitive organism was inhibited by clostocin 0 infection. The amounts of macromolecules of the infected organism were held at the initial level. The fate of the macromolecules in clostocin O-infected organism was investigated by using of isotope labeled compounds. The permeability for glucose or phenylalanine was held for 15 min after clostocin 0 infection. The biosyntheses of lipid and protein were somcwhat moderately inhibited within 15 min after clostocin 0 infection, whereas the biosyntheses of DNA and RNA were immediately inhibited after clostocin 0 infection. However, degradation of DNA was not observed. From these results, we suggest that clostocin 0 strongly inhibits the synthesis of nucleic acids in short time.続きを見る
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