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2,2ʼ,3,4ʼ,5,6,6ʼ-七塩素化ビフェニル(CB188)のラットおよび モルモット肝ミクロゾームによる代謝

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概要 The metabolism of a 2,4,6-trichloro-substituted PCB, 2,2ʼ,3,4ʼ,5,6,6ʼ-heptachlorobiphenyl (CB188), by rat and guinea pig liver microsomes was compared to that of a 2,4,5-trichloro-substituted PCB, 2,2...ʼ,3,4ʼ,5,5ʼ,6-heptachlorobiphenyl (CB187) using liver microsomes of untreated, phenobarbital (PB)-treated and 3-methylcholanthrene (MC)-treated rats and guinea pigs. Two metabolites, M1 and M2, were produced only by liver microsomes of PB-treated rats with rates of 554 and 187 pmol/hr/mg protein, respectively, but no metabolite by liver microsomes of untreated and MCtreated rats. In addition, no metabolite was observed by all kinds of guinea pig liver microsomes used in this study. GC-MS revealed that both M1 and M2 were mono-hydroxylated CB188. Also, the methylated M1 almost completely agreed with a synthesized authentic 3ʼ-methoxy-CB188 in terms of the retention times and mass fragmentation. These results suggest that 3ʼ-OH-CB188 is a major metabolite formed by PB-inducible CYP2B enzymes in rats and that the 2,4,6-trichloro-substituted PCBs are metabolized much more easily than the 2,4,5-trichloro-substituted PCBs続きを見る
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登録日 2019.07.22
更新日 2019.07.23

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