Effect of Cu^2+ on the browning reaction of triose reductone (TR) with amino acids was investigated. Browning was remarkably promoted with Cu^2+, especially in the 1:2 reaction system of TR with some amino acids such as glycine, aspartic acid, glutamic acid, tryptophan, arginine and phenylalanine. But in other reaction system, the browning was about the same or less than that without Cu^2+. On the other hand, the browning by the 1:2 reaction system was always more predominant than the 1:1 reaction with or without Cu^2+. Then, the variation of absorption spectra of the reaction mixture of TR, amino acids and Cu^2+ was also estimated. The characteristic absorption of TR decreased with the reaction time. Especially in the 1:2 reaction system, the increase of the absorption at near 225 and 310 nm, suggesting the formation of condensation products, was also observed. Furthermore, the spots supposed to be condensation products were detected paperchromatographically in all reaction mixtures.