In view of importance of reductones which has been emphasized in our institute on the basis of the studies concerning the connection of food constituents and cancer, the antitumoric potentiality of some derivatives of ascorbic acid was investigated using sarcoma-180. The potentiality of dehydroascorbic acid was confirmed by administering it of higher purity than that employed in the preceding study, even in the experiments of much longer period. Erythorbic acid and its oxidized form, dehydroerythorbic acid, have also the antitumoric potentiality, although with less efficiency than ascorbic acid and dehydroascorbic acid. As observed with reductones, viscosity of DNA was reduced by erythorbic or dehydroerythorbic acid in the presence of Cu^2+. Ascorbyl-monopalmitate which has also enediol group caused some repression of the growth of tumor too. However, when oxidized form of enediol group in dehydroascorbic acid had been blocked with o-phenylenediamine, decomposing ability on DNA as well as the antitumoric potentiality of dehydroascorbic acid were lost. Thus, in this study, some additional support were presented to our demonstration that the initial step in cancer repression by reductones may be due to the appropriate depolymerization of DNA.
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