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An imaging technique for the detection of magnetic nanoparticles (MNPs) has been studied for biomedical applications. First, a detection system, which measures the second harmonic signal from the MNPs..., was designed and developed based on nonlinear propertied of the MNPs under strong excitation field. By measuring the second harmonic signal, interference of the excitation field can be significantly reduced, when compared to the case of measuring the fundamental signal. Using this system, we could detect 100 μg of MNPs which were located at z=30mm under the detection coil. The detected signal field was 128 pT at the measurement frequency of 38.6 kHz, and the signal to noise ratio was as high as 10. Next, a field map from the MNPs was measured, and a clear contour map was obtained. The obtained contour map agreed well with numerical simulations. Using the contour map, we could directly estimate the position of markers. Finally, a field map from two markers, which were separated with a distance Δx, was measured in order to study the ability of position identification of two markers. It was shown that we could distinguish two markers located at z=20mm if they were separated by Δx=20mm. This simple detection system could be applied for the detection of sentinel lymph node during the biopsy.続きを見る
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