|This study examined patients with Kanemi Yusho. The patients' height, weight, and bone mineral density were measured. The density of the distal end of the radius was measured using dual energy X-ray a...bsorptiometry and the calcaneum was measured with ultrasound. We also measured urine levels of cross-linked N-telopeptides of type I collagen, serum tartrate-resistant acid phosphatase 5b, serum bone-specific alkaline phosphatase, serum Ca, serum P and blood PCB level. The patient group that took PCBs when they were 0 to 18 years old (such patients were 42 to 60 years old at the time of the study) showed no correlation between the bone density of the radius and calcaneum in spite of treatment received when they were over 18 years of age (＞60 years of age at the time of the study). The bone mineral density in Kanemi Yusho was not different from the controlgroup. The levels of only serum bone-specific alkaline phosphatase were correlated with the bonemineral density of the radius and calcaneum in patients treated when they were over 18 years of age (currently over 60 years old). PCBs might have had an effect on bone density and bone metabolism.
PCB やダイオキシンは，骨代謝に影響を及ぼし，骨粗鬆症を誘発する可能性が指摘されている．しかし，一定の見解はない．長崎県のカネミ油症検診者を対象とした検討では，検診者の30% に骨粗鬆症が認められ，骨量減少群は25％に認められた．しかし，PCB やダイオキシン類が骨粗鬆症を誘発する，もしくは骨代謝に影響を及ぼすかどうか不明である．また，PCB などの骨代謝への影響は人の発育時期でも異なる可能性を考慮し，長崎県カネミ油症検診者をカネミ油症事件発生時18 歳以下と19 歳以上の2 群に分けて，骨密度と骨代謝の影響を検討した．続きを見る