| 概要 |
We measured the concentrations of polychlorinated dizenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and non-ortho-coplanar polychlorinated biphenyls (Co-PCBs) in blood collected from 2...79 Yusho patients and 92 Yusho-suspected persons living in Japan in 2002, 269 Yusho patients and 74 Yusho-suspected persons living in Japan in 2003 and 128 normal controls living in Fukuoka Prefecture, and compared with the concentrations of these compounds among the groups. The total TEQ concentrations of PCDDs, PCDFs, and Co-PCBs in the blood of Yusho patients were 3.6 times and 3.3 times higher than those in the normal controls in 2002 and 2003, respectively. In the case of Yusho-suspected persons, the concentrations were 1.1 times and 1.0 times higher in 2002 and 2003, respectively. Among the TEQ concentrations of PCDDs, PCDFs, and Co-PCBs, the concentrations of PCDFs in the blood of Yusho patients were 10.3 times and 9.4 times higher than those of the normal controls in 2002 and 2003, respectively, whereas the concentrations of PCDDs and Co-PCBs in blood were identical in Yusho patients, Yusho-suspected persons and normal controls. Yusho patients indicated the highest concentrations ratio of PCDFs to the total TEQ concentrations. Moreover, of the PCDFs congeners for Yusho patients, the concentrations of 2,3,4,7,8-PeCDF were about 11.0 times and 10.1 times higher in 2002 and 2003 than those in normal controls. These results indicated that Yusho patients have a much higher concentration of 2,3,4,7,8-PeCDF in their blood than do unaffected persons even though over 34 years have passed since the outbreak of Yusho.
平成14年度に日本在住の279名の油症患者と92名の未認定者,平成15年度に日本在住の269名の油症患者と78名の未認定者および福岡県在住の一般健常人128名から採取した血液中のPCDDs,PCDF,およびCo-PCBs濃度を測定し,これら化合物の濃度を比較した.平成14および15年度に受診した油症患者の血液中PCDDs,PCDF,およびCo-PCBsの総TEQ濃度は,それぞれ一般健常人の3.6倍および4.5倍であった.未認定者の場合,血液中ダイオキシン類の総TEQ濃度は,それぞれ一般健常人の1.1倍および1.0倍であった.油症患者の血液中PCDDsおよびCo-PCBs濃度は,ほぼ健常人と同レベルなのに対し,PCDFs濃度は健常人のそれぞれ10.3倍(平成14年)および9.4倍(平成15年)高い値を示した.総TEQ濃度に対するPCDDs,PCDFsおよびCo-PCBs濃度の割合を比較した場合,油症患者のPCDFs濃度は総濃度の約8割を占めていた.PCDFs異性体間で特に高濃度を示す2,3,4,7,8-PeCDFは,健常人のそれぞれ11.0倍(平成14年)および10.1倍(平成15年)高い値を示した.以上の結果から,油症発症から34年経過した現在も患者の血中PCDFs濃度,特に2,3,4,7,8-PeCDF濃度は依然高いレベルにあり,新しい油症診断基準を策定する上で最も重要な要素と考えられる.続きを見る
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Mendeley出力
fam96_5_p249