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Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

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概要 A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in ou...r ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.続きを見る
目次 Protein Folding Intermediates
Pathways and Mechanism of Protein Folding
The Folding Pathway of Apomyoglobin
Circular Dichroism Stopped-Flow Studies of Folding Intermediates
Native-like Intermediates in Protein Folding
A First-Order Phase Transition Between a Compact Denatured State and a Random Coil State in Staphylococcal Nuclease
Studies in Protein Stability
Studies on 'Hyperstable' Proteins: Crystallins from the Eye-Lens and Enzymes from Thermophilic Bacteria
Origins of Mutation Induced Stability Changes in Barnase: An Analysis Based on Free Energy Calculations
Basic Interactions
Monte Carlo Simulation of Electrostatic Interactions in Biomolecules
The Molecular Origin of the Large Entropies of Hydrophobic Hydration
Statistical Mechanical Models and Protein States
Statistical Mechanics of Secondary Structures in Proteins: Characterization of a Molten Globule-like State
Hydrophobic Zippers: A Conformational Search Strategy for Proteins
Theoretical Perspectives on In Vitro and In Vivo Protein Folding
On the Configurations Accessible to Folded and to Denatured Proteins
Exploring Conformation Space
Experiences with Dihedral Angle Space Monte Carlo Search for Small Protein Structures
Constrained Langevin Dynamics of Polypeptide Chains
MOIL: A Molecular Dynamics Program with Emphasis on Conformational Searches and Reaction Path Calculations
Flexibility in the Fc Region of Immunoglobulin G
NMR Data and Protein Structure
Computer-Supported Protein Structure Determination by NMR
Enumeration with Constraints: A Possible Approach to Protein Structure Reconstruction from NMR Data
A Decomposition of the nOe Intensity Matrix
Membrane Proteins
Structure and Dynamics of Membrane Proteins
Steps Toward Predicting the Structure of Membrane Proteins
The Protein Data Base: Fold Families and Structure Prediction
Protein Fold Families and Structural Motifs
Data Based Modeling of Proteins
Applications of Knowledge Based Mean Fields in the Determination of Protein Structures
A New Approach to Protein Folding Calculations
Knowledge Based Potentials for Predicting the Three-Dimensional Conformation of Proteins
Protein-Substrate Interactions
Protein-Protein Recognition: An Analysis by Docking Simulation
Molecular Dynamics Simulation of an Antigen-Antibody Complex: Hydration Structure and Dissociation Dynamics
Multiple Conformations of Cystatin, Mung Bean Inhibitor and Serpins
Structure and tRNA Phe-Binding Properties of the Zinc Finger Motifs of HIV-1 Nucleocapsid Protein
Electrostatic Complementarity in Protein-Substrate Interactions and Ligand Design
Molecular Engineering in the Preparation of Bioactive Peptides
Author Index.
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登録日 2020.06.27
更新日 2020.06.28