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Statistical Analysis of Next Generation Sequencing Data

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概要 Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that... surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized medicine. About the editors: Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville. He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics, and Elected Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics, Biostatistics and Bioinformatics. Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University.  He is Fellow of the American Statistical Association and has published research on a variety of topics in statistics, biology, and bioinformatics.続きを見る
目次 Statistical Analyses of Next Generation Sequencing Data: An Overview
Using RNA-seq Data to Detect Differentially Expressed Genes
Differential Expression Analysis of Complex RNA-seq Experiments Using edgeR
Analysis of Next Generation Sequencing Data Using Integrated Nested Laplace Approximation (INLA)
Design of RNA Sequencing Experiments
Measurement, Summary, and Methodological Variation in RNA-sequencing
Functional PCA for differential expression testing with RNA-seq data
Mapping of Expression Quantitative Trait Loci using RNA-seq Data
The Role of Spike-In Standards in the Normalization of RNA-seq
Cluster Analysis of RNA-sequencing Data
Classification of RNA-seq Data
Isoform Expression Analysis Based on RNA-seq Data
RNA Isoform Discovery Through Goodness of Fit Diagnostics
MOSAiCS-HMM: A Model-based Approach for Detecting Regions of Histone Modifications from ChIP-seq Data
Hierarchical Bayesian Models for ChIP-Seq Data
Genotype Calling and Haplotype Phasing from Next Generation Sequencing Data.- Analysis of Metagenomic Data
Detecting Copy Number Changes and Structural Rearrangements using DNA Sequencing
Statistical Methods for the Analysis of Next Generation Sequence Data from Paired Tumor-Normal Samples
Statistical Considerations in the Analysis of Rare Variants.
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本文を見る Full text available from Springer Mathematics and Statistics eBooks 2014 English/International

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登録日 2020.06.27
更新日 2020.06.28