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Molecular Mechanisms of Angiogenesis : From Ontogenesis to Oncogenesis

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概要 Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood ...but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells,...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.続きを見る
目次 Emergence of Endothelial Cells During Vascular Development
Lymphatic Vascular Morphogenesis
Finding New Partnerships; The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors
Wnt/ Frizzled Signaling in the Vasculature
BMP9, BMP10 And ALK1: An Emerging Vascular Signaling Pathway With Therapeutic Applications
Apeling Signaling in Retinal Angiogenesis
Emerging Role of the Two Related Basic Helix-Loop-Helix Proteins
TAL1 and LYL1 In Angiogenesis
Hypoxia and Extracellular Matrix Remodeling
Sphingosine-1-Phosphate in Hypoxic Signaling
Reciprocal Crosstalk Between Angiogenesis and Metabolism
Endothelial Progenitor Cells and Cardiovascular Ischemic Diseases: Characterization, Functions and Potential Clinical Applications as Biomarker and Therapeutic Tools
Endothelial Cell Reactions to Oxygen: Implications For Cancer
Tumor Angiogenesis and Lymphangiogenesis: Microenvironmental Soil For Tumor Progression And Metastatic Dissemination
Angiogenesis And Invasion in Malignant Glioma: Friends or Foes?
Role of Endothelial Cells in Tumor Escape From Immunity
Tumor High-Endothelial Venules and Lymphocyte Trafficking
Post-Transcriptional Regulation of Angiogenesis Through AU-Rich Mrna Degradation: Potential Application in Cancer Therapy
Antiangiogenic Drugs in Cancer Therapy, Effect on Advanced Renal Cell Carcinoma
Anti-Angiogenic Therapies in Colorectal Cancer
Resistance to Anti-Angiogenic Treatments via Up-Regulation of Substitution Pathways
VEGF-A Splice Variants: Do They Play a Role in Tumor Responses to Anti-Angiogenic Therapies?
Progenitor Endothelial Cells as Biomarkers of Anti-Vascular Agents
Soluble Vascular Endothelial (VE)-Cadherin : Toward a Marker of Endotelial Dysfunction
The Prognostic and Predictive Value of VEGF Across Various Tumor Types.
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本文を見る Full text available from Springer Biomedical and Life Sciences eBooks 2014 English/International

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登録日 2020.06.27
更新日 2020.06.28