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Molecular mechanisms and physiology of disease : Implications for Epigenetics and Health

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概要 In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulati...on in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.続きを見る
目次 Epigenetics in Childhood Health and Disease
Role of Epigenetics in Neural Differentiation: Implications for Health and Disease
An Overview of Epigenetic Mechanisms in Health and Disease
Epigenetics: Role of Histone Proteases in Cellular Functions and Diseases
Anti-inflammatory Effects of Probiotics and their Metabolites - Possible Role for Epigenetic Effects
Epigenetics of Autoimmune Diseases
The Effect of Nutrition and Exercise on Epigenetics and the Development of Cardiovascular Disease
Epigenetic Events Associated with Obesity and Diabetes
Molecular Mechanisms in the Development and Progression of Asthma: The Role of Epigenetic Regulation and the Airway Epithelium
The Significance of Nanoparticles in Medicine and their Potential in Asthma
One-carbon Metabolism Nutrients and Epigenetics: A Mechanistic Link Between Aberrant One-carbon Metabolism and Cancer Risk?
Principles of the Warburg Effect and Cancer Metabolism
Molecular Aspects of the Warburg Effect
Epigenetic Perturbations in the Context of the Multi-hit Hypothesis of Carcinogenesis
Epigenetic Mechanisms of Colon Cancer Prevention
Dietary Antioxidants and Chromatin Modifying Compounds as Potential Anticancer Therapies
Combination Therapy for Cancer - Phototherapy and HDAC Inhibition
Nano-base Drug Delivery Modalities for the Treatment of Cancer: The Formulation of Tumour-specific and -targeted Nanoparticles.
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本文を見る Full text available from Springer Biomedical and Life Sciences eBooks 2014 English/International

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登録日 2020.06.27
更新日 2020.06.28