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Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

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概要 In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the s...ynthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.続きを見る
目次 Peroxisome biogenesis and function: History and Discovery of peroxins
Human cell lines to study peroxisome biogenesis.-Mouse models to study peroxisome biogenesis
Metabolic interaction between peroxisome and Mitochondria
Peroxisomal Diseases:The Zellweger spectrum
Molecular basis
PEX11beta
Peroxisome morphology in pathologies
Other peroxisome-related disorders
New technologies applied to study peroxisomes: Bioinformatics
Imaging in plant and peroxules
Tools to study peroxisomes as signaling platform: oxidative stress studies and antiviral innate immunity
Proteomic approach. Protein transport across the peroxisomal membrane: The matrix protein import complex in yeast
Protein transport in plant peroxisomes
Concept Exportomer
Factors involved in ubiquitination/deubiquitination of PEX5
Peroxisome dynamics: Trafficking of the peroxisome biogenesis factor PEX3 through the ER
Role of PEX3 and PEX19 in peroxisome membrane biogenesis
Vesicles, reticulon and ER-to-peroxisome contact sites
Pex11 proteins and their alpha-helix
Molecular complex coordinating peroxisome morphogenesis
Dynamin-related proteins. Specific degradation through pexophagy: Principle of selective organelle degradation: Factors involved in pexophagy in the yeast Pichia pastoris.
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本文を見る Full text available from Springer Biomedical and Life Sciences eBooks 2014 English/International

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登録日 2020.06.27
更新日 2020.06.28