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Microglia in Health and Disease

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概要 These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were s...hown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly what they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.続きを見る
目次 Introduction
Historical Context
Microglial Physiology
Lessons from in vivo Imaging
Roles in Immune Responses
Neuroprotection Versus Neurotoxicity
Developmental Neuronal Elimination
Developmental Angiogenesis, Myelination and Astrogliogenesis
Developing and Mature Synapses
Adult Neurogenesis, Learning and Memory
Neuropathic Pain
Drug Addiction
Aging
Neurodevelopmental and Neuropsychiatric Disorders
Human Immunodeficiency Virus
Multiple Sclerosis
Ischemia and Stroke
Neurodegenerative Diseases
Spinal Cord and Brain Trauma.
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本文を見る Full text available from Springer Biomedical and Life Sciences eBooks 2014 English/International

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登録日 2020.06.27
更新日 2020.06.28