<電子ブック>
Microbial Biochemistry

責任表示
著者
本文言語
出版者
出版年
出版地
概要 This book focuses on microbial physiology, biochemistry, and genetics and provides the reader with detailed information on a number of microbial pathways. Insight into microbial biochemistry allows fo...r the formulation of concepts which have turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery which is indispensable for the comprehension of many regulatory mechanisms described throughout the book. The second section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The fifteen chapters after that deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.続きを見る
目次 Bacterial growth
The outer membrane of Gram-negative bacteria and the cytoplasmic membrane
Peptidoglycan synthesis and cell division
Cellular permeability
Allosteric enzymes
Glycolysis, gluconeogenesis, glycogen and cellulose biosynthesis
The pentose phosphate and Entner-Doudoroff pathways
The tricarboxylic acid cycle and the glyoxylate bypass
ATP-generating processes. Respiration and Fermentation
Biosynthesis of lipids
Iron-sulfur proteins
The Archaea
Methanogens and methylotrophs
Enzyme induction in catabolic systems
Transcription. RNA polymerase
Negative regulation
Enzyme repression in anabolic pathways
Positive regulation
The Ribosomes, Translation, Chaperones and Chaperonins
The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases
Attenuation
Regulation by RNAs and Riboswitches
The biological fixation of nitrogen
How biosynthetic pathways have been established
The aspartic acid family of amino acids.-Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae
Other patterns of regulation of the synthesis of amino acids of the aspartate family
Biosynthesis of the amino acids of the glutamic acid family and its regulation
Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid
Selenocysteine and selenoproteins
Biosynthesis of aromatic amino acids and its regulation
The biosynthesis of histidine and its regulation
The biosynthesis of nucleotides
The biosynthesis of deoxyribonucleotides
Biosynthesis of some water-soluble vitamins and of their coenzyme forms
Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones
Biosynthesis of the tetrapyrrole ring system
Biosynthesis of cobalamins including vitamin B12
Interactions between proteins and DNA
Evolution of biosynthetic pathways.
続きを見る
本文を見る Full text available from Springer Biomedical and Life Sciences eBooks 2014 English/International

詳細

レコードID
主題
SSID
eISBN
登録日 2020.06.27
更新日 2020.06.28