<紀要論文>
Novel Inhibitors of Phenylalanine Ammonia-lyase: 5-Aryl-1, 3, 4-oxathiazol-2-ones

作成者
本文言語
出版者
発行日
雑誌名
開始ページ
終了ページ
出版タイプ
アクセス権
概要 A series of 5-aryl-1,3,4-oxathiazol-2-ones was synthesized and tested for inhibition against phenylalanine ammonia-lyase (PAL) derived from the yeast Rhodotorula glutinis. All compounds inhibited PAL ...at 100 μM. Of the compounds tested, 5-(4-nitrophenyl)-1,3,4-oxathiazol-2-one (19) was the most effective, showing IC50 value of 2.5 μM, which was 2 times stronger than that of N-(aminooxy) acetyl-2,5-dichloroaniline (Z302), a known PAL inhibitor. Compound 19 behaved as a noncompetitive inhibitor of PAL. When potato tuber disks were treated with 19 in the presence of laminarin, a β-1,3-glucooligosaccharide elicitor, the amount of trans-cinnamic acid diminished after 48 hr, being consistent with an effective inhibition of PAL. Most of the compounds inhibited the growth of lettuce seedlings at 100-500μM. However, no correlation was observed between the ability of 5-aryl-1,3,4-oxathiazol-2-ones to inhibit PAL derived from R. glutinis and growth inhibitory activity against lettuce seedlings.続きを見る

本文情報を非表示

p309 pdf 356 KB 307  

詳細

レコードID
査読有無
関連情報
主題
ISSN
NCID
タイプ
登録日 2009.04.22
更新日 2017.09.01