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＜学術雑誌論文＞
Maternal Exposure to Fine Particulate Matter and Its Chemical Components Increasing the Occurrence of Gestational Diabetes Mellitus in Pregnant Japanese Women
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| 概要 | Introduction: PM_<2.5> exposure is a suspected risk factor for diabetes. It is hypothesized that maternal PM_<2.5> exposure con- tributes to the development of gestational diabetes mellitus (GDM). The... association between PM_<2.5> exposure and GDM is controversial and limited evidence is available for the exposure to PM_<2.5> chemical components. We investigated the associa- tion between maternal exposure to total PM_<2.5> mass and its components, particularly over the first trimester (early placenta- tion period), and GDM. Methods: Data were obtained from the Japan Perinatal Registry Network database, which includes all live births and still- births after 22 weeks of gestation at 39 cooperating hospitals in 23 Tokyo wards (2013-2015). At one fixed monitoring site, we performed daily filter sampling of fine particles and measured daily concentrations of carbon and ion components. The average concentrations of total PM_<2.5> and its components over the 3 months before pregnancy and the first (0-13 gestational weeks) and second (14-27 gestational weeks) trimesters were calculated and assigned to each woman. We estimated the odds ratios (ORs) of GDM in a multilevel logistic regression model. Results: Among 82,773 women (mean age at delivery = 33.7 years) who delivered singleton births, 3,953 (4.8%) had GDM. In the multiexposure period model, an association between total PM_<2.5> exposure and GDM was observed for exposure over the first trimester (OR per interquartile range (IQR = 3.63 μg/m^3) increase = 1.09; 95% confidence interval (CI) = 1.02-1.16), but not for the 3 months before pregnancy or the second trimester. For PM_<2.5> components, only organic carbon exposure over the first trimester was positively associated with GDM (OR per IQR (0.51 μg/m^3) increase = 1.10; 1.00-1.21). Conclusions: This is the first evidence that exposure to total PM_<2.5> and one of its components, organic carbon, over the first trimester increases GDM occurrence in Japan.続きを見る |
詳細
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| 登録日 | 2024.07.11 |
| 更新日 | 2024.07.11 |