<紀要論文>
Asymmetric Synthesis of 3-(1-Phenylethylamion)-1-propanol from 3-[(1-Phenylethylidene) amino] propene by a Sequence of Hydroboration/Imine Reduction

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概要 A new synthetic method consisting of a hydroboration/imine reduction sequence is described. Hydroboration of 3-[(1-phenylethylidene) amino]-propene with optically pure isopinocanpheylborane is followe...d by the reaction with diethylzinc and then the oxidation with hydrogen peroxide to produce 3-(1-phenylethylamino)-1-propanol with a moderate enantioselectivity. The alkylborane produced in the hydroboration step forms a chiral five-membered complex structure which induces the new chirality in the imine reduction step.続きを見る

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登録日 2009.04.22
更新日 2017.05.10