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油症患者におけるFBRA 摂取による油症原因PCDFs同族体の体外排泄促進

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概要 Thirty-eight years have passed since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several obj...ective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the causative agents, that is, polychlorinated dibenzofurans (PCDFs)and polychlorinated dibenzo-p-dioxins (PCDDs)from the bodies of the patients and to reduce their body burdens. In rats,dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll, in eighteen patients with Yusho, which were divided into two groups, namely group A, ten patients (Male: 3 and Female: 7)with the mean age of 67.7 years old and group B,eight patients (Male: 4 and Female: 4) with the mean age of 64.1 years. Respective mean concentrations of the three PCDF congeners, that is, 2,3,4,7,8-PenCDF, 1,2,3,4,7,8-HxCDF and 1,2,3,6,7,8-HxCDF in the blood on whole weight basis just before initiating this study were as follows; group A : 1.36,0.491 and 0.150 pg/g,and group B : 0.571,0.159 and 0. 064 pg/g. Contamination levels of these PCDF congeners in group A were 2 to 3 times higher than those in group B. Group A took 7.0 to 10.5g of FBRA after each meal and tree times a day for the first one year and for second one year, they did not take FBRA any more. Group B took FBRA with the same manner as the group A only for the second one year. The concentrations of these PCDFs congeners in the blood of groups A and B were also measured at the end of first and second year,respectively. Assuming that the lipid content of the blood is 0.3% in order to convert their concentrations on whole weight basis to those on lipid weight basis and also that the body fat is contaminated with these PCDF congeners at their concentrations on lipid weight basis and the content of body fat is 20% of the body weight (60 kg),we computed the average amounts in the net excretion of these PCDF congeners from the body of the patients due to the intake of FBRA in groups A and B. As a result,in group A,120,372 and 96 ng/patient of 2,3,4,7,8-PenCDF, 1,2,3,4,7,8-HxCDF and 1,2,3,6,7,8-HxCDF,respectively,were excreted from the body of the patients. In group B,however,36 ng/patient of 2,3,4,7,8-PenCDF only was excreted,but other two PCDF congeners were not. Accordingly, promotive excretion of theses PCDF congeners from the patients with Yusho seemed much effective in group A,of which their concentrations in the blood were much higher than those of group B.
カネミ油症中毒事件が発生してから38年が経過したが,今でも油症患者は種々様々な自覚および臨床症状で苦しんでいる.このような症状を改善し治療するには,その主要な原因物質であるポリ塩化ダイベンゾフラン(PCDFs)を積極的に体外へ排泄し,汚染レベルを低下させることが第一である.この研究では動物実験によりダイオキシン類の体外排泄促進作用が認められている食物繊維と葉緑素を比較的多量に含む栄養補助食品FBRA(発酵玄米栄養補助食品ハイ・ゲンキ,㈱玄米酵素,本社:北海道札幌市)によるカネミ油症原因物質,中でも特に重要な2,3,4,7,8-五塩化ダイベンゾフラン(2,3,4,7,8-PenCDF),1,2,3,4,7,8-六塩化ダイベンゾフラン(1,2,3,4,7,8-HxCDF)および1,2,3,6,7,8-六塩化ダイベンゾフラン(1,2,3,6,7,8-HxCDF)の体外排泄促進を18名の油症患者の協力により調べた.研究期間は2年間で,患者の希望によりA,B 二群に分け,A 群は最初の1年間,B 群は2年目の1年間,毎食後7.0~10.5g のFBRA を摂取した.A 群は10名(男性3名,女性7名)で,平均年齢が67.7歳,B 群は8名(男性4名,女性4名)で,平均年齢が64.1歳であった.研究を始める前の血中PCDFs同族体の平均濃度はA 群が2,3,4,7,8-PenCDF ; 1.36pg/g,1,2,3,4,7,8-HxCDF ; 0.491pg/g,1,2,3,6,7,8- HxCDF ; 0.150pg/g で,B 群が,それぞれ0.571,0.159,0.064 pg/g であった.A 群のほうが,2~3倍高かった.研究開始1年後と2年後にも両群の血中PCDFs同族体濃度を測定した.これらの測定結果より,血液の脂肪含有率を0.3%として,脂肪重量当りの濃度を算出した.この濃度で患者体内の脂肪組織が汚染されており,体重60kg の患者について,体脂肪率を20%と仮定して,これらのPCDFs同族体の体内蓄積量を算出する.そして,この体内蓄積量がFBRA 摂取と非摂取の期間でどのように変化するかを,両群で比較検討した.A 群の場合,すべてのPCDFs同族体でFBRA 摂取期間のほうが非摂取期間よりも減少量が多く,平均純減少量は患者一人当り2,3,4,7,8-PenCDF が120ng,1,2,3,4,7,8-HxCDF が372ng,1,2,3,6,7,8-HxCDF が96ng であった.B 群では2,3,4,7,8-PenCDF のみ,36ng 減少したが,他の二種の同族体では体外への排泄促進は認められなかった.以上の結果より,FBRA には油症の原因となったPCDFs同族体の体外排泄促進作用が認められ,その効果は汚染レベルの高い患者でより有効と考えられた.
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登録日 2009.04.22
更新日 2017.07.31