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24時間尿中カリウム排泄量推定法に関する研究 : 尿中クレアチニン排泄量予測値と分割尿を用いた推定法の基礎的検討

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概要 The purpose of this study is to estimate 24-hour urinary potassium excretion (24HUKV) from the predicted value (Predicted Cr) for 24-hour urinary creatinine excretion (24HUCrV) and the fractional urin...e K/Cr ratio (FK/FCr) by means of the following equations; 24HUCrV≒Predicted Cr........................ (1) 24HUKV/24HUCrV∝FK/FCr............... (2) The following propotional expression will be derived from (1) and (2), 24HUKV∝FK/FCr×predicted Cr. Equation to predict 24HUCrV from age, body weight (BW) and body height (BH) was developed based on the data for the mean 24HUCrV determined by 24-hour urine collected for at least 3 days from 487 clinically healthy subjects. The method of forward stepwise regression analysis was adopted to establish the regression equation. The equations for men and for women obtained from age (years), BW (kg) and BH (cm) were follows; Predicted Cr for men (mg/day)=-12.6×Age+15.1×BW+7.4×BH-80 Predicted Cr for women (mg/day)=-4.7×Age+8.6×BW+5.1×BH-75 The multiple correlation coefficients were 0.872 for men and 0.727 for women, respectively. Three hundred and thirty-four clinically healthy subjects were studied to estimate 24 HUKV. Four-hour fractional urine specimens were collected for ensuing 24 hours starting at 0800h. The correlations were determined between 24HUKV/24HUCrV and FK/FCr ratio for 0400-0800h, 0800-1200h, 1200-1600h and 0000-0800h, respectively. The values calculated from the formula X: (X= FK/FCr for each fractional urine × predicted Cr) were closely correlated with 24HUKV measured, the best correlation coefficient being 0.787 for 1200-1600h fractional urine. The estimated 24HUKV was obtained from the following formula: Estimated 24HUKV (mEq/day) =0.406×X*+20.6 X*=FK/FCr for 1200-1600h×Predicted Cr. This equation may be applied for estimating potassium intake in clinical studies or epidemiological surveys. (Journal of Health Science, Kyushu University, 9: 133-136, 1987)続きを見る

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登録日 2009.09.10
更新日 2018.06.12