<紀要論文>
Synthesis and Structure-Activity Relationships of 6-Methyl-3-pyridyl Ethers as Anti-juvenile Hormone Agents

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概要 A series of 6-Methyl-3-pyridyl 2-(substituted phenoxy)etyl ethers and related compounds were synthesized and evaluated against 72-hour old 3rd-instar larvae of the silkworm,Bombyx mori, for their acti...vity to induce precocious metamorphosis. A chloro substituent at the 3-position on the benzene ring and chain length of two carbon aatoms between the two oxygen atoms were important fot this activity. Replacemant of 6-Methyl-3-pyridyl portion with 3-pyridyl or various substituted prydyl groups completely eliminated the activity, indicationg that the 6-Methyl-3-pyridyl ether moiety indispensable for the activity. Ofthe compounds tested, 2-(3-chlorophenoxy) ethyl 6-Methyl-3-pyridyl ether (1) was the most effective. Precocius metamorphosis induced by compound 1 was accompanied by the prolongation of the larval period and could be fully counteracted by methoprene, a juvenile hormone agonist.続きを見る

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登録日 2009.04.22
更新日 2017.02.02