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赤血球膜ナトリウム輸送に関する研究

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概要 Na-influx in red cells was measured in normotensive and borderline hypertensive subjects using the Mahoney's method. In normotensives, Na-influx was higher in males than in females, and also in offspr...ing of hypertensives than in those without familial predisposition of hypertension, compared between age-matched groups. Influence of age on Na-influx was unclear in both sex groups. In male subjects, Na-influx showed higher values in 14 borderline hypertensives than in 12 normotensives, and also higher in 9 women with high normal blood pressure (Hi-BP) than in 12 women with low normal blood pressure (Lo-BP). To test the effect of Na and K intake on Nainflux, Hi-BP and Lo-BP groups were given 200-220 mEq of Na and 40-50 mEq of K one by one, in addition to a normal intake of 100-120 mEq Na and 40-50 mEq K per day. Na load significantly increased Na-influx in Hi-BP group, but did not in Lo-BP group. On the other hand K load insignificantly decreased Na-influx in Lo-BP group, but unchanged in Hi-Bp group. In young men, Na-influx from 21 borderline hypertensives was statistically significantly increased after one-hour upright position, whereas that from 12 normotensives unchanged. Responsibility of Na-influx to upright position was not significantly correlated with blood pressure in either group. In order to investigate the mechanism of changes in Na-influx, variables other than blood pressure should be taken into account. Six healthy women, 22 years of age, stayed in RISM (Rational Intensive Self Measurement) rooms, Kyushu University for 3 days seasonally. Four-hourly blood sampling revealed circadian variation of Na-influx. Its peak appeared at around midnight. No report has been made on circadian rhythm of Na-influx. Its detection and explanation remain to be resolved. When we assess Na transport in cell membrane, conditions such as sampling time, position and Na intake should be considered.続きを見る

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登録日 2009.09.10
更新日 2018.06.12