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The factors influencing the urinary creatinine excretion were stuclied in clinically healthy subjects. The results obtained were as follows : (1). The intraindividual and interindividual coefficients ...of variation (CV) of urinary creatinine excretion (UcrV) were determined in 4 male (28 to 43 years old) and 4 female subjects (27 to 54 y.o.) over the period of 18 to 24 days of the daily urine collections. The intraindividual CV of UcrV was 5.5 to 11.9r%, an average of 9.2%, whereas the interindividual CV of UcrV was as large as 30.0%. (2). UcrV was measured in 580 subjects and was classified by age and sex. UcrV was always higher in rnales than in females and it gradually decreased with age in only males. Correlation coefficient was calculated between UcrV and other variables, such as age, body height, body weight, body surface area (BSA). Quetelet index (BMI), urine volume (UV), urinary Na and K excretion, urinary Na/K (mEq) ratio and blood pressure, in 308 male (18 to 82 v.o.) ancl 272 female subjects (19 to 79 y.o.). It was founci that correlation coefficient between UcrV and BSA was the highest in males (γ＝0.681, P＜0.001) and that between UcrV and age in females (r＝-0.651, p＜0.001). Correlation coefficients were also high between UcrV and age (r＝-0.649, P＜0.001), body weight. (r＝0.620, P＜0.001) or body height (r＝0.575, p＜0.001) in males and between UcrV and body height (r＝0.572, p＜0.001) or BSA (r＝O 517 P＜0.001) in females. There was; no significant correlation between UcrV and UV in both sexes. (3). To observe the influence of exercise on UcrV, 6 female subjects (26 to 35 y.o.) were asked to take exercise by means of ergometer, and UcrV was measured before, during and after exercise. UcrV between the day of and the day after exercise was also compared. There was an insignificant decrease in UcrV during exercise. However, no statistically significant changes were observed among UcrV before, during and after exercise, and between the day of and the day after exercise. (4). To observe the influence of the different amount. or salt ingestion on UcrV and on the circadian rhvthm, UcrV was measured on 2g, 10g and 22g/day of salt ingestion for 4 days, respectively, and on 120 mg/day of furosemide administration for 3 days in 9 male subjects (19 to 25 y.o.). No significant difference of UcrV was found among the 4 different conditions. (5). Four-hour fractional urine was collectd to detect the circadian rhythm of UcrV in 9 male subjects on the last day of each 3 different amount of salt ingestion for consecutive 24 hours. Marked and identical circadian rhythms of UcrV were detected regardless of the different amount of salt ingestion. These results suggest that the different amount of salt ingestion does not. affect the excretion and the rhythm characteristics of UcrV. Age, sex and physique should be fully considered in case of applying creatinine ratio to the evaluation of the excretion in urine variables.続きを見る
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