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| 概要 |
Urinary excretions of sodium, potassium, chloride, creatinine, aldosterone and kallikrein, and their circadian rhythms were investigated in 14 male subjects with borderline essential hypertension (H-G...roup) and in 7 normal male subjects (N-Group). The averages of age, body height, body weight and body mass index in the two groups were similar. Urine collections for circadian analysis of variables were made every. 4 hours for 24 hours. The value for 24-hour urine was calculated using the values obtained from the total of 4-hour urine collections. Circadian rhythm was analyzed by multivariate statistical method (cosinor method). H-Group excreted in urine an average of 208.6 mEq sodium and 208.3 mEq chloride per day, whereas the corresponding values determined for N-Group were 147.4 and 147.8 mEq/ day, respectively. The differences in excretion between the two groups were statistically significant (p＜0.01) . Other variables, however, showed no differences in excretion between the two groups. Circadian rhythms were detected in all variables in H-Group and in all but kallikrein excretion in N-Group. The characteristics of the circadian rhythms in all variables but the acrophase (phase of peak in circadian rhythm) in sodium excretion did not show the difference in the two groups. The acrophase of the circadian rhythm in sodium excretion in urine was detected 4 hours earlier in H-Group than in N- Group. This phenomenon was consistent with that in established moderate essential hypertension in our previous studies.続きを見る
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