多発肺癌におけるProgrammed death-ligand 1 の発現とEGFR遺伝子変異 - 九大コレクション | 九州大学附属図書館

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＜博士論文＞
多発肺癌におけるProgrammed death-ligand 1 の発現とEGFR遺伝子変異

	Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer
作成者	作成者姓名原武, 直紀 Haratake, Naoki ハラタケ, ナオキ
論文調査委員	橋爪, 誠
	中西, 洋一
	中山, 敬一
本文言語	英語
学位授与年度	2017
学位授与大学	九州大学
学位授与大学	Kyushu University
学位	博士（医学）
学位種別	課程博士
アクセス権	metadata only access
関連DOI	https://doi.org/10.1016/j.athoracsur.2017.09.025
概要	BACKGROUND:Little is known about the programmed death-ligand 1 (PD-L1) expression in multifocal lung cancer, such as the expression in multiple primary lung cancer and pulmonary metastasis. In this tr...anslational study, we investigated PD-L1 expression and its relationship with the epidermal growth factor receptor (EGFR) mutation status in resected multifocal lung cancer. METHODS:The PD-L1 expression in 152 samples of multifocal lung cancer from 59 patients was evaluated by an immunohistochemical analysis. RESULTS: Among the 152 lung cancer lesions of 59 patients, PD-L1 expression was observed in 29 lesions (19.1%) of 20 patients (33.9%). Among 43 patients with 112 multiple primary lung cancer lesions, 15 lesions (13.4%) of 13 patients (30.2%) were PD-L1 positive; and among 16 patients with 40 pulmonary metastatic lesions, 14 lesions (35.0%) of 7 patients (43.8%) were PD-L1-positive. Among 43 patients with multiple primary lung cancer, there was disagreement of PD-L1 expression in 12 patients (27.9%, κ = 0.104). On the contrary, among 16 patients with pulmonary metastasis, disagreement of PD-L1 expression was observed only in 1 patient (6.3%, κ = 0.871). In pulmonary metastatic lesions, the frequency of PD-L1 positivity among lesions with wild-type EGFR was significantly higher than among lesions with mutated EGFR (66.7% versus 0%: p < 0.001). CONCLUSIONS:This study provides important evidence of higher levels of agreement of PD-L1 expression in pulmonary metastasis compared with in multiple primary lung cancer, and high positivity of PD-L1 expression in pulmonary metastatic lesions with wild-type EGFR in an Asian population.続きを見る

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ファイル	ファイルタイプ	サイズ	閲覧回数	説明
med3128_abstract	pdf	119 KB	248	要旨
med3128_summary	pdf	119 KB	224	要約
med3128_review	pdf	167 KB	223	審査結果要旨

詳細

レコードID	1931814
査読有無	査読有
権利関係	やむを得ない事由により本文ファイル非公開 (2)
権利関係	Public access to the fulltext file is restricted for unavoidable reason (2)
関連PubMed ID	29254651
報告番号	17102甲第13961号
学位記番号	医博甲第3128号
授与日(学位/助成/特許)	2018-03-31
受理日	2018-03-02
部局	医博
登録日	2018.05.30
更新日	2018.08.31