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Synthesis of 7-ω-Amidoalkyl-substituted 6,7-Dehydroestra-3,17β-diols

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Abstract The entry to the novel C7-alkylsubstituted 6,7-dehydroestrones 10 by addition of C-nucleophiles on the enolate of suitably protected 6-ketoestrone derivative 3, reduction of the 6-keto group in 7, deh...ydration of 6-hydroxy group in 8 with a subsequent deprotection step is presented. An exemplary transformation of 10 to the 17α-iodoethynylestradiol 12 is shown.show more

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Created Date 2009.04.22
Modified Date 2020.12.09

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