Mendeley出力
＜学術雑誌論文＞
Gut-protective metabolic phenotype for diarrhoeal remission caused by an environmental probiotic thermophile
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| 概要 | Background Controlling diarrhoea in humans and livestock is a global challenge with diverse aetiologies. However, the dynamics of the microbiome for diarrhoeal remission are not sufficiently understood..., and effective intervention strategies based on environmental microorganisms have not been fully explored. Methods We investigated the metabolic structure associated with diarrhoeal remission using a combination of statis- tical, genomic, and proteomic approaches in a cattle model. Oral administration of the compost-derived thermophile Caldifermentibacillus hisashii significantly ameliorated persistent diarrhoea. Faecal bacterial populations and metabo- lites were characterised by a multi-step statistical pipeline comprising difference-in-differences (DID) analysis, Cliff’s delta effect size estimation with permutation-based validation. The functional importance of the selected feature components was validated through genomic and proteomic analysis of C. hisashii N11 (AP028807.1). Results Oral administration of C. hisashii significantly ameliorated persistent diarrhoea in calves. Although no sig- nificant differences in faecal bacterial community composition were observed, integrated analysis of faecal metabo- lites identified butyrate and 2-aminoisobutyrate (AIB) as the most discriminative features associated with diarrhoeal remission. Genomic and proteomic analyses of C. hisashii confirmed biosynthetic gene clusters for butyrate and AIB- containing lantibiotics, supporting the structural importance of these metabolites in diarrhoeal remission. Conclusion These findings suggest that diarrhoeal remission observed in this study involves characteristic shifts in faecal metabolite profiles rather than marked changes in overall gut microbial community composition, highlight- ing a protective role of C. hisashii as an environmental probiotic against diarrhoeal dysbiosis through modulation続きを見る |
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| 登録日 | 2026.08.17 |
| 更新日 | 2026.08.20 |