<journal article>
Green Synthesis and Characterization of a Hydrazone-Based Copper Complex with Antibacterial Activity: Experimental and DFT Studies

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Abstract This research focused on the green synthesis, experimental and computational structure analysis, and investigation of the antibacterial properties of a copper complex with Schiff base ligand, (Z)-2-(1...-(2-phenylhydrazineylidene)ethyl)phenol. The ligand was synthesized from phenylhydrazine and o-hydroxyacetophenone with an acetic acid catalyst. The Cu(II) complex was synthesized by reacting CuSO4·5H2O with the ligand in methanol, using mole ratios of 1:4 and 1:1 with the addition of KOH at room temperature. The ligand was coordinated to Cu(II) via N-H and O-H groups. Electronic spectra at 643 nm suggested square planar geometry. The complex demonstrated higher antibacterial activity than most tested bacteria.show more

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Created Date 2026.07.03
Modified Date 2026.07.08