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The utility of carbonate apatite (CO_3Ap) as a bone substitute has been demonstrated. The feasibility of fabricating macroporous CO_3Ap was evaluated through a two-step dissolution–precipitation react...ion using gypsum as the precursor and spherical phenol resin as the porogen. Porogen-containing gypsum was heated to burn out the porogen and to fabricate macroporous structures. Gypsum transformed into CaCO_3 upon immersion in a sodium carbonate solution, while maintaining its macroporous structure. Next, CaCO_3 transformed into CO_3Ap upon immersion in a Na_2HPO_4 solution while maintaining its macroporous structure. The utility of the macroporous CO_3Ap for histologically reconstructing bone defects was evaluated in rabbit femurs. After 4 weeks, a much larger bone was formed inside the macroporous CO_3Ap than that inside non-macroporous CO_3Ap and macroporous hydroxyapatite (HAp). A larger amount of bone was observed inside non-macroporous CO_3Ap than inside macroporous HAp. The bone defects were completely reconstructed within 12 weeks using macroporous CO_3Ap. In conclusion, macroporous CO_3Ap has good potential as an ideal bone substitute.続きを見る
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