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At the onset of exercise, the demand for ATP increases, and cannot be met by the aerobic ATP provision. Consequently, the increased need for ATP must be met by the anaerobic ATP provision. The limit...ation in pulmonary oxygen uptake (VO2) kinetics may be due to 1) limited availability of O2 to the mitochondria caused by an extrinsic inertia of convective and diffusive O2 transport mechanisms, or 2) the inertia of intrinsic cellular metabolism signals and enzyme activation. Numerous experimental approaches have been applied to test these hypotheses in humans. Evidence for each hypothesis has been found, though a precise explanation for the limitation remains unclear. In this paper, we examined the effects of factors in each cascade on VO2 kinetics, and confirmed the validity of near infrared spectroscopy (NIRS), which reflects the insufficiency of muscle O2 transport in relation to the muscle O2 uptake, for purposes of investigating the last cascade in active muscle tissue. In addition, we discussed the effects of oxidative enzyme activities on VO2 kinetics.show more
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