Export

Link to this page

Please use this URL for citations.

Search Other Services

Statistics

  • Access to this page：167 times

＜journal article＞
Modification of the C3-Position of 2,3-Dehydro-2-deoxy-N-acetylneuraminic Acid with An Acetic Acid Equivalent

Creator
Creator Name
Uezono, Keiya
上薗, 慶也
ウエゾノ, ケイヤ
Affiliation
Affiliation Name
Graduate School of Pharmaceutical Sciences, Kyushu University
九州大学大学院薬学府創薬科学専攻
Creator Name
Maeda, Risa
前田, 梨紗
マエダ, リサ
Affiliation
Affiliation Name
Graduate School of Pharmaceutical Sciences, Kyushu University
九州大学大学院薬学府創薬科学専攻
Author PID
K007240
0000-0003-2182-3914
Creator Name
Yoritate, Makoto
寄立, 麻琴
ヨリタテ, マコト
Affiliation
Affiliation Name
Graduate School of Pharmaceutical Sciences, Kyushu University
九州大学大学院薬学研究院創薬科学部門
Author PID
K008016
Creator Name
Matoba, Hiroaki
的場, 博亮
マトバ, ヒロアキ
Affiliation
Affiliation Name
Graduate School of Pharmaceutical Sciences, Kyushu University
九州大学大学院薬学研究院創薬科学部門
Author PID
K006452
0000-0003-3420-555X
Creator Name
Hirai, Go
平井, 剛
ヒライ, ゴウ
Affiliation
Affiliation Name
Graduate School of Pharmaceutical Sciences, Kyushu University
九州大学大学院薬学研究院創薬科学部門
Language
English
Publisher
Oxford University Press
Chemical Society of Japan
日本化学会
Date
2022-12-20
Source Title
Chemistry Letters
Vol
52
Issue
2
First Page
71
Last Page
74
Access Rights
metadata only access
Rights
Public access to the fulltext file is restricted by copyright reason.
著作権処理未完了のため本文ファイル非公開
Related DOI
https://doi.org/10.1246/cl.220507
Related URI
Abstract Direct modification at the C-3 position of 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA) derivatives with malonates has been achieved by means of Mn(OAc)_3-mediated oxidative coupling reaction, g...iving C3-modified DANA derivatives in good yield with high diastereo-selectivity. We also designed and synthesized 3-CH_2COOH-DANA as a candidate sialidase inhibitor, but found that its inhibitory activity towards several sialidases was weak, possibly because the acidic functional group is located too close to the DANA skeleton.show more

Details

PISSN
0366-7022
EISSN
1348-0715
NCID
AA12179675
Record ID
7173602
Subject Terms
Oxidative coupling
Sialic acids
Sialidase inhibitors
Type
Journal Article
Funding Information
Funder Name
Japan Agency for Medical Research and Development
日本医療研究開発機構
Award Title
PRIME, BINDS, and SCARDA
Funder Name
Japan Society for the Promotion of Science (JSPS)
日本学術振興会
Award Number
22K14683
Award Title
Development of a new method for generating glycosyl radical and application to C-glycosylation
新規グリコシルラジカル発生法の開発と無保護C-グリコシル化反応への応用
Funder Name
Japan Society for the Promotion of Science (JSPS)
日本学術振興会
Award Number
21K19053
Award Title
中分子グライコミメティクスの開拓
Funder Name
Japan Society for the Promotion of Science (JSPS)
日本学術振興会
Award Number
21H02070
Award Title
Synthetic chemistry for the development of oligosaccharide-type sialidase inhibitors
遷移状態ー基質ハイブリッドアナログ型酵素阻害剤の創製
Funder Name
Mizutani Foundation for Glycoscience
水谷糖質科学振興財団
Funder Name
Takeda Science Foundation
武田科学振興財団
Created Date 2024.04.22
Modified Date 2024.04.22

People who viewed this item also viewed