Creator |
|
|
|
|
|
Language |
|
Publisher |
|
|
|
Date |
|
Source Title |
|
Vol |
|
Issue |
|
First Page |
|
Last Page |
|
Access Rights |
|
Rights |
|
|
Related DOI |
|
Related URI |
|
Abstract |
Direct modification at the C-3 position of 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA) derivatives with malonates has been achieved by means of Mn(OAc)_3-mediated oxidative coupling reaction, g...iving C3-modified DANA derivatives in good yield with high diastereo-selectivity. We also designed and synthesized 3-CH_2COOH-DANA as a candidate sialidase inhibitor, but found that its inhibitory activity towards several sialidases was weak, possibly because the acidic functional group is located too close to the DANA skeleton.show more
|