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To know the characteristics of 24-hour variations of blood pressure(BP) and pulse rate (PR), ambulatory BP was monitored automatically every 30 minutes for 24-26 hours with non-invasive device, ABPM-6...30 (Nippon Colin Co.) in healthy volunteers (18-years of age). Four hundred and forty eight subjects (249 men and 199 women) joined in this study. Oscillometric method was superior in the numbers of detected measurements, whereas Korotkoff method had more failed measurements. After attachment of a device. BP and PR decreased gradually and significantly by the third measurement. BP at the beginning of measurement was significantly higher than that at the same time on the next day. Twenty four hour averages of SBP and DBP were always higher in men than in women. The most distinctive factor of circadian variation was the sleep-wake cycle, with BP being lowest during sleep in men and women. While awake, SBP was highest in the afternoon in men, and in the morning in women. Circadian variations of BP and PR in women shifted forward as compared with those in men. Twenty four hour BP varied in averages and patterns by age and gender, and taking these differences into account, the reference range of circadian variation of BP may be established by age-group and gender.show more
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