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＜journal article＞
The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes

Creator
Author PID
K004153
0000-0002-6483-3074
Creator Name
Kawakubo-Yasukochi, Tomoyo
川久保-安河内, 友世
カワクボ-ヤスコウチ, トモヨ
Creator Alternative Name
Yasukochi, Tomoyo
安河内, 友世
ヤスコウチ, トモヨ
Kawakubo, Tomoyo
川久保, 友世
カワクボ, トモヨ
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Creator Name
Morioka, Masahiko
モリオカ, マサヒコ
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野
Creator Name
Hayashi, Yoshikazu
ハヤシ, ヨシカズ
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野
Author PID
30600035
Creator Name
Nishinakagawa, Takuya
西中川, 拓也
ニシナカガワ, タクヤ
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Author PID
10509186
Creator Name
Hazekawa, Mai
櫨川, 舞
ハゼカワ, マイ
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Author PID
K002902
00398067
Creator Name
Kawano, Shintaro
川野, 真太郎
カワノ, シンタロウ
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野
Author PID
K001027
Creator Name
Nakamura, Seiji
中村, 誠司
ナカムラ, セイジ
Affiliation
Affiliation Name
Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野
Author PID
50198074
Creator Name
Nakashima, Manabu
中島, 学
ナカシマ, マナブ
Affiliation
Affiliation Name
Department of Immunological and Molecular Pharmacology, Faculty of Pharmaceutical Science, Fukuoka University
福岡大学薬学部
Language
English
Publisher
Elsevier
Date
2016-02
Source Title
Journal of Oral Biosciences
Vol
58
Issue
1
First Page
33
Last Page
38
Access Rights
metadata only access
Rights
Public access to the fulltext file is restricted by copyright reason.
著作権処理未完了のため本文ファイル非公開
Related DOI
https://doi.org/10.1016/j.job.2015.10.001
Related URI
Abstract Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine... the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells and subsequently reduced mRNA expression of cytokeratin 13, which is strongly linked to malignant transformation of OSCCs. The results suggest that multiple cell clones secrete their unique exosomes within the malignant tumor mass, which mediate paracrine interactions with other cell clones and affect clinical prognosis.show more

Details

PISSN
1349-0079
NCID
AA12057113
Record ID
5909140
Subject Terms
Oral squamous carcinoma cells
invasion
exosome
Notes
Published version is available for viewing only. (See "Related DOI")
「関連DOI」より出版社版の閲覧専用ページへリンク
Type
Short Communication
Created Date 2022.12.05
Modified Date 2022.12.05

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